Document Type
Article
Abstract
Bioassay-guided fractionation of an active fraction from an extract of a marine starfish, Novodinia antillensis, led to the isolation and identification of two new saponins, Sch 725737 (1) and Sch 725739 (2). Compound 1 was identified as the NaV1.8 inhibitor with IC50 of _9 lM. The purification and the structure elucidation of these two saponins are described.
DOI
10.1016/j.bmcl.2007.08.025 (doi)
Publication Date
2007
Recommended Citation
The final published version of this manuscript is available at http://www.sciencedirect.com/science/journal/0960894X and may be cited as: Yang, S.-W., Chan, T.-M., Buevich, A., Priestley, T., Crona, J., Reed, J., Wright, A. E., Patel, M., Gullo, V., Chen, G., Pramanik, B., & Chu, M. (2007). Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis. Bioorganic & Medicinal Chemistry Letters, 17(20), 5543-5547. doi:10.1016/j.bmcl.2007.08.025
Comments
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1677.