Document Type
Article
Abstract
A new marine-derived macrolide designated as neopeltolide (1) has been isolated from a deep-water sponge of the family Neopeltidae. Its structure was elucidated on the basis of spectroscopic data interpretation. Neopeltolide (1) is a potent inhibitor of the in vitro proliferation of the A-549 human lung adenocarcinoma, the NCI-ADR-RES human ovarian sarcoma, and the P388 murine leukemia cell lines, with IC50’s of 1.2, 5.1, and 0.56 nM, respectively. Neopeltolide (1) also inhibited the growth of the fungal pathogen Candida albicans with a minimum inhibitory concentration of 0.62 íg/mL.
DOI
10.1021/np060597h (doi)
Publication Date
2007
Recommended Citation
This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np060597h. This article may be cited as: Wright, A. E., Botelho, J. C., Guzmán, E., Harmody, D., Linley, P., McCarthy, P. J., Pitts, T. P., Pomponi, S. A., & Reed, J. K. (2007). Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae. Journal of Natural Products, 70(3), 412-416. doi:10.1021/np060597h
Comments
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1649.