PLAKOLIDE A, A NEW γ‐LACTONE FROM THE MARINE SPONGE PLAKORTIS SP.

Authors

Sarath P. Gunasekera, Florida Atlantic University
Richard A. Isbrucker, Florida Atlantic University
Ross E. Longley, Florida Atlantic University
Amy E. Wright, Florida Atlantic University
Shirley A. Pomponi, Florida Atlantic University
John K. Reed, Florida Atlantic University

Author Type

Faculty

Document Type

Article

Abstract

Plakolide A (1), a new R-exomethylene-ç-lactone isolated from the marine sponge Plakortis sp., was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described.

DOI

10.1021/np030294c (doi)

Publication Date

2004

Comments

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1536.

Recommended Citation

This document is the accepted manuscript version of a published work that appeared in final form in Journal of Natural Products after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/np030294c. This article may be cited as: Gunasekera, S. P., Isbrucker, R. A., Longley, R. E., Wright, A. E., Pomponi, S. A., & Reed, J. K. (2004). Plakolide A, a New γ-Lactone from the Marine Sponge Plakortis sp. Journal of Natural Products, 67(1), 110-111.