TWO NEW CYTOTOXIC LINDERAZULENES FROM A DEEP-SEA GORGONIAN OF THE GENUS PARAMURICEA.

Authors

N. Srinivasa Reddy, Florida Atlantic University
John K. Reed, Florida Atlantic University
Ross E. Longley, Florida Atlantic University
Amy E. Wright, Florida Atlantic University

Author Type

Faculty

Document Type

Article

Abstract

The known compound linderazulene (1) and two new linderazulenes (2, 3) were isolated from a deep-sea gorgonian Paramuricea sp. The structures of 2 and 3 were determined through spectroscopic methods. Compounds 1-3 show moderate in vitro cytotoxicity against the P388 murine leukemia cell line with IC50’s of 18.8, 2.7, and 15.6 íg/mL, respectively. Compound 2 showed moderate activity against the PANC-1 pancreatic cell line with an IC50 of 18.7 íg/mL.

DOI

10.1021/np040147u (doi)

Publication Date

2005

Comments

Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1571.

Recommended Citation

Thisarticle may be cited as: Reddy, N. S., Reed, J. K., Longley, R. E., & Wright, A. E. (2005). TwoNew Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea. Journal of Natural Products, 68(2), 248-250.