Document Type
Article
Abstract
A series of analogs of the immunosuppressive lipopeptide microcolin A has been prepared and evaluated for in vitro activity in the human and murine two-way mixed lymphocyte reaction. The compounds tested were obtained by semisynthetic modification and chemical degradation of the natural product. The relative potencies of these analogs suggest that the hydroxyproline and 5-methyl-3-pyrrolin-2-one portion of the molecule are important for immunosuppressive activity and that other structural elements may play an ancillary role. Methanolysis of microcolin A also led to a novel immunosuppressive lactone analog.
DOI
10.1021/jm00045a024
Publication Date
1994
Recommended Citation
This article may be cited as: Koehn, F. E., McConnell, O. J., Longley, R. E., Sennett, S. H., & Reed, J. K. (1994). Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity. Journal of Medicinal Chemistry, 37(19), 3181-3186. doi:10.1021/jm00045a024
Comments
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1050.