Date of Award

2020

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Wetterer, James

Abstract

Intervertebral disc disease, or IVDD, involves damage to the discs between vertebrae in the spinal column of vertebrates. The disease is progressive and has a significant genetic component as well as influences from the patient’s lifestyle. This thesis examines IVDD in canines, evaluating the cause, currently available and under research treatment options, and considers future research into mitigating the severity of disease progression. Results suggest that with current knowledge, a combination of surgical correction and conservative management yields the best outcome for the patient, decreasing in effectiveness as the disease progresses. Novel treatment options include cell-based, gene, and growth factor therapies that have greater potential with severe cases. This paper suggests targeting the root of the problem to minimize the extent of treatment needed. Educating breeders and pet owners to catch the early onset of the disease will not only minimize detriment to the patient but also increase the number of cases seen by veterinarians, which will allow a greater understanding of the disease’s mechanisms and increased knowledge for laboratory work. The One Health concept allows the transfer of knowledge of the disease between human and veterinary medicine, which should be pushed to further expand the research of IVDD.

Comments

Includes bibliography.

Extent

35 p.

Identifier

FA00013660

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