Date of Award

2019

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Carvelli, Lucia

Abstract

Drug tolerance can be defined as a progressive reduction in the effect of a drug following a previous exposure. Amphetamine (AMPH) is a psychostimulant which produces its behavioral effects primarily by an increase extracellular dopamine (DA) level. In C. elegans, this surplus of extracellular DA causes the loss of the ability to swim, also called swimming induced paralysis (SWIP). Here we tested if C. elegans could build up a tolerance for AMPH. Two separate groups of L4 animals were tested for an initial SWIP trial: a control 1st-treated group and an AMPH 1st-treated group. Both groups had 3 recovery periods and reassessed for a 2nd SWIP trial with control or AMPH solutions. Our results show that the first exposure to AMPH reduces the number of animals exhibiting SWIP when treated for the second time with AMPH 30 minutes after the first exposure.

Comments

Includes bibliography.

Extent

18 p.

Identifier

FAUHT00111

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