Date of Award

2019

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Maldonado, Monica

Abstract

Syngap1 haploinsufficiency is among the most common genetically identified cause of intellectual disability along with epilepsy and autism spectrum disorder. Syngap1 regulates a critical period during development by coordinating dendrite elongation and synaptic maturation/plasticity in forebrain areas. This project aims to better understand how disruption of Syngap1 during developmental critical periods impact circuit assembly and brain function. To understand how impaired circuit assembly may lead to neural dysfunction, whole-brain mapping of neural activation in Syngap1 mutants was performed. This study aims to reveal how variants linked to genetically defined human brain disorders effect neural circuit structure and function at the mesoscale.

Comments

Includes bibliography.

Extent

27 p.

Identifier

FAUHT00096

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