Date of Award

2019

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Bohn, Laura

Abstract

Opioid agonists are potent pain relievers that have serious side effects including respiratory suppression, dependence, and addiction. Biased agonism refers to a ligand dependent selectivity for specific down stream signaling pathways, which can be used as a model of receptor function in effort to develop safer analgesics. By changing the ligand, activated G-protein-coupled receptors can be manipulated to activate desired intracellular pathways, which results in positive clinical effects, e.g. analgesia, without activation of pathways that result in negative clinical effects, e.g. respiratory suppression and dependency. This thesis project will explore the in vitro and in vivo results of bias at the ��-opioid receptor (��OR), specifically investigating G-protein-preferential activation with reduced βarrestin2 recruitment, a regulatory protein responsible for many negative effects.

Comments

Includes bibliography.

Extent

31 p.

Identifier

FAUHT00090

Download

Share

COinS