EXAMINATION OF LOCAL AND LONG DISTANCE EFFECTS OF NUCLEOTIDE SUBSTITUTIONS IN SECONDARY RNA STRUCTURES

Author

• Daniela Giachetti

Date of Award

2019

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Trivigno, Catherine

Abstract

Researchers are currently designing RNAs for diagnostic and therapeutic applications, and an understanding of the factors that affect stability of these RNAs could inform the design of new RNA constructs. This project involved the use of in silico experiments to investigate the effects of different nucleotide substitutions on the stability of RNAs using EteRNA, a publicly available, online computer modeling software developed by researchers at Carnegie Mellon and Stanford Universities to study RNA folding. It was determined that while many types of single nucleotide substitutions can alter the stability of secondary structures, such as loops, the stability of adjacent structures was not affected.

Comments

Includes bibliography.

Recommended Citation

Giachetti, Daniela, "EXAMINATION OF LOCAL AND LONG DISTANCE EFFECTS OF NUCLEOTIDE SUBSTITUTIONS IN SECONDARY RNA STRUCTURES" (2019). Harriet L Wilkes Honors College Theses 2010 - 2019. 424.
https://digitalcommons.fau.edu/etd_honors_2/424

Extent

40 p.

Identifier

FAUHT00075