Date of Award
2019
Document Type
Dissertation/Thesis
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Cudic, Predrag
Abstract
Peptides provide a promising avenue for the development of novel medicinal compounds due to their active role in brain and nervous system function. Odorranalectin, the smallest known lectinomimic compound, is a naturally derived peptide. When administered intranasally, Odorranalectin bypasses the blood-brain barrier via the the L-fucose region of the olfactory system. Thus, Odorranalectin can act as a carrier for other central nervous system active peptides, such as analgesics. Once released into the brain, the active peptide fragments bind to opioid receptors, providing pain relief. Novel mu (μ), kappa (κ), and delta (δ) opioid receptor selective OL-based ligands were identified in binding assays and individual peptides were synthesized, purified and characterized. Analgesic effects were observed in acute as well as chronic pain models in rodents. This strategy could be a promising alternative to current treatments for pain.
Recommended Citation
Kovic, Matthew, "SYNTHESIS OF ODORRANALECTIN ANALOG PEPTIDES TARGETING OPIOID RECEPTORS: A NOVEL STRATEGY IN PAIN MANAGEMENT" (2019). Harriet L Wilkes Honors College Theses 2010 - 2019. 395.
https://digitalcommons.fau.edu/etd_honors_2/395
Extent
40 p.
Identifier
FAUHT00114
Comments
Includes bibliography.