A STUDY TO IDENTIFY THE TRANSCRIPTIONAL BINDING PARTNERS FOR THE NUCLEAR RECEPTORS REV-ERB α AND REV-ERB β IN THE REGULATION OF TH17 CELL DEVELOPMENT

Author

• Oliver Pelletier

Date of Award

2018

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Moore, Jon

Abstract

The nuclear receptors REV-ERBα (NR1D1) and REV-ERBβ (NR1D2) play a major role in the regulation of the circadian rhythm. They work together with the nuclear receptor RORγt in gene activation and repression at RORE sites. These sites are found in TH17 cells that are known for their production of proinflammatory cytokines causing chronic inflammation, which is a prominent feature in many autoimmune diseases. In this study, the REVERBα/REVERBβ binding complex was examined for its role in the expression of a known target gene, BMAL1. Furthermore, additional investigations were conducted to elucidate the roles that REVERBα and REVERBβ have in the immune system and to identify protein binding partners in the REVERB complex.

Comments

Includes bibliography.

Recommended Citation

Pelletier, Oliver, "A STUDY TO IDENTIFY THE TRANSCRIPTIONAL BINDING PARTNERS FOR THE NUCLEAR RECEPTORS REV-ERB α AND REV-ERB β IN THE REGULATION OF TH17 CELL DEVELOPMENT" (2018). Harriet L Wilkes Honors College Theses 2010 - 2019. 366.
https://digitalcommons.fau.edu/etd_honors_2/366

Extent

42 p.

Identifier

FAUHT00039