MYC-induced repression of Tristetraprolin alters the expression of are-containing genes in prostate cancer

Author

• Evan Altman

Date of Award

2011

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Quintyne, Nicholas

Abstract

Prostate cancer has the second highest mortality rate of all cancers in men. The Myc oncoprotein is misregulated in 70% of all cancers, including 70% of prostate cancers, and affects several cancer mechanisms. Myc is able to directly repress the expression of Tristetraprolin (TTP). TTP regulates mRNA stability by binding to select mRNAs. Furthermore, TTP is able to suppress Myc‐driven B cell lymphoma in mice. In these studies, cell culture models were used to access the role of Myc-induced repression of TTP in prostate cancer. Prostate cancer cells lines were identified with inverse expression of Myc and TTP. Additionally, ARE‐containing genes with roles in various cancer mechanisms were differentially expressed in these models. These findings suggest that Myc’s ability to downregulate TTP is important in prostate cancer and provide new avenues for treating Myc‐driven prostate cancer.

Comments

Includes bibliography.

Recommended Citation

Altman, Evan, "MYC-induced repression of Tristetraprolin alters the expression of are-containing genes in prostate cancer" (2011). Harriet L Wilkes Honors College Theses 2010 - 2019. 33.
https://digitalcommons.fau.edu/etd_honors_2/33

Extent

47 p.

Identifier

FA00003554