UNC-33 and RPM-1 Function in Parallel to Regulate Axon Termination

Author

• Rayna Birnbaum

Date of Award

2016

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Kirchman, Paul

Abstract

Precise axon termination is necessary for the development of a functioning neuronal network within the nervous system. However, little is known about the mechanisms that regulate axon termination. C. elegans RPM-1, a conserved member of the PHR proteins, has been previously shown to regulate axon termination and synapse formation. Recently, it was shown that, when phosphorylated by Cdk5, CRMP-2 (the mammalian homolog of C. elegans UNC-33) acts as a microtubule destabilizer during axon outgrowth. We investigated the relationship between the RPM-1 and UNC-33 pathways in axon termination. Our data has lead to the conclusion that the CDK-5, UNC-33 pathway works in parallel with the RPM-1 pathway to regulate axon termination.

Comments

Includes bibliography.

Recommended Citation

Birnbaum, Rayna, "UNC-33 and RPM-1 Function in Parallel to Regulate Axon Termination" (2016). Harriet L Wilkes Honors College Theses 2010 - 2019. 256.
https://digitalcommons.fau.edu/etd_honors_2/256

Extent

15 p.

Identifier

FA00003665