A STUDY TO ELUCIDATE THE INTERACTION OF MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP) AND HYPOXIA-INDUCIBLE FACTOR 1-ALPHA (HIF-1α) IN PANCREATIC CANCER

Author

• Michelle E. Gras

Date of Award

2024

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Trivigno, Catherine

Abstract

Pancreatic cancers are difficult to treat with a 13% survival rate. Factors such as hypoxic niches within the cancer promote drug resistance, while enzymes such as membrane-type 1 matrix metalloproteinase (MT1-MMP) are linked to disease etiology. MT1-MMP’s transmembrane region is implicated in cancer invasion and metastasis. However, little is known about the cytoplasmic tail (MT1-MMP-CT). Recent studies have linked MT1-MMP-CT and the transcription factor, hypoxia-inducible-factor-1-subunit-alpha (HIF-1α); a transcription factor that is stable only under hypoxia. This study uses flow cytometry to quantify the co expression of HIF-1α and MT1-MMP-CT among human pancreatic cell lines, under both normoxia and hypoxia. This study seeks to understand more about the relationship between MT1-MMP and HIF-1α in normoxic and hypoxic conditions within pancreatic cancer.

Comments

Thesis (B.S.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2024

Recommended Citation

Gras, Michelle E., "A STUDY TO ELUCIDATE THE INTERACTION OF MEMBRANE-TYPE 1 MATRIX METALLOPROTEINASE (MT1-MMP) AND HYPOXIA-INDUCIBLE FACTOR 1-ALPHA (HIF-1α) IN PANCREATIC CANCER" (2024). Harriet L Wilkes Honors College Theses 2020 - Present. 252.
https://digitalcommons.fau.edu/etd_honors/252

Extent

33 p.

Identifier

FAUHT00305