Date of Award
2013
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Abstract
Cone snails are carnivorous marine mollusks, utilizing their neuropeptide-rich venom for prey capture. The venom of Conus brunneus, a wide-spread Eastern Pacific vermivore, has not been extensively studied. In the current work, peptides from the dissected venom were characterized and tested using preliminary bioassays. Six peptides (A-F) were isolated and tested. Three peptide identities were determined by comparison with previously reported data: bru9a (A), bru3a (F), and an a-conotoxin (E). Preliminary screening in a stroke-related model of induced glutamate excitotoxicity in primary neuronal cells and PC12 cell cultures indicated potential neuroprotective activity of peptide fractions A, D, and F. Further testing is necessary to determine and verify structure, activity, target, and mechanism of action of the promising peptides from C. brunneus, which may prove effective neuropharmacological agents to treat stroke.
Extent
xiii, 85 p. : ill. (some col.)
Recommended Citation
Crouch, Rebecca A., "Neuroprotection from induced glutamate excitotoxicity by Conus brunneus conopeptides in a stroke-related model" (2013). Electronic Theses and Dissertations 2010 - 2019. 828.
https://digitalcommons.fau.edu/etd_general_6/828
Identifier
FADT3362331
Comments
by Rebecca A. Crouch.|Thesis (M.S.)--Florida Atlantic University, 2013.|Includes bibliography.|Mode of access: World Wide Web.|System requirements: Adobe Reader.|by Rebecca A. Crouch.