Date of Award
2012
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Abstract
Adult neurogenesis is affected in neurodegenerative diseases and also represents an important therapeutic target. The goal of this dissertation research was to test the hypothesis that regeneration of neurons and glia in the adult brain can be manipulated by neurotrophic drugs in the context of two mouse models of neurodegenerative disease : Parkinson's disease and Huntington's disease.... These findings have implications for the pathophysiology of Huntington's disease and neurodegeneration in general. Specific alterations to the SVZ neurogenic niche parallel some of the pre-motor symptoms of Parkinson's disease and Huntington's disease. This dissertation research contributes to the growing body of literature concerning the pharmacological modulation of SVZ-derived neurogenesis designed to attenuate the progressive loss of neurons in neurodegenerative diseases and perhaps delay the onset of symptoms.
Extent
xiv, 135 p. : ill. (some col.)
Recommended Citation
McCollum, Mark Harvey, "Modulation of adult neurogenesis in mouse models of neurodegenerative disease" (2012). Electronic Theses and Dissertations 2010 - 2019. 587.
https://digitalcommons.fau.edu/etd_general_6/587
Identifier
FADT3355626
Comments
by Mark Harvey McCollum.|Vita.|Thesis (Ph.D.)--Florida Atlantic University, 2012.|Includes bibliography.|Mode of access: World Wide Web.|System requirements: Adobe Reader.|by Mark Harvey McCollum.