Author Type

Graduate Student

Date of Award

2012

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Abstract

Restrictive cardiomyopathy (RCM) is a cardiac muscle disorder characterized by increased ventricular stiffness and diastolic dysfunction. Patients with RCM often present severe cardiac problems which usually lead to heart failure and sudden death. No effective treatment is available for RCM which makes the finding of novel efficient therapies an urgent necessity. Great progress in molecular biology techniques and advances in transgenic animal development provide great opportunities for the study of RCM and other cardiovascular diseases encountered in clinical patients.... Our laboratory is among the first to generate transgenic mouse models of RCM based on cardiac troponin I (cTnI) missense mutations. In this study, transgenic mice that suffer from RCM have been generated to understand the factors behind the diastolic dysfunction associated with that myocardial disease.... The information obtained from this study allows a better understanding of the role of troponin in RCM and the factors behind the physiopathology of the disease. It will also offer a therapeutic strategy taking into account the physiological characteristic of RCM.

Extent

xv, 122 p. : ill. (some col.)

Comments

by Pierre-Ives Jean-Charles.|Thesis (Ph.D.)--Florida Atlantic University, 2012.|Includes bibliography.|Mode of access: World Wide Web.|System requirements: Adobe Reader.|by Pierre-Ives Jean-Charles.

Identifier

FADT3358554

Format

pdf

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