Anterograde trophic signaling in the olfactory system: neurotrophin-3 expressed by olfactory sensory neurons is transported to target bulb neurons in adult mice

Author

• Huan Liu

Author Type

Graduate Student

Date of Award

2012

Document Type

Dissertation

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Guthrie, Kathleen M.

Abstract

The adult rodent olfactory system provides an excellent model for the study of the developing nervous system due to its constant integration of new neurons and establishment of new synapses throughout life. This allows for adaptive structural responses to sensory experience that continuously shape functional circuits to fit the behavioral needs of the animal. The cellular mechanisms underlying the anatomical plasticity of the adult olfactory system are not well understood, but neurotrophins, long recognized as crucial to the early development of neuronal circuits, are attractive candidate molecules in this capacity. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), two members of the neurotrophin family, have received attention in terms of their anatomical distribution and physiological functions in the olfactory system.

Extent

106 p.

Comments

Includes bibliography.|Dissertation (Ph.D.)--Florida Atlantic University, 2012.|Includes bibliography.

Recommended Citation

Liu, Huan, "Anterograde trophic signaling in the olfactory system: neurotrophin-3 expressed by olfactory sensory neurons is transported to target bulb neurons in adult mice" (2012). Electronic Theses and Dissertations 2010 - 2019. 449.
https://digitalcommons.fau.edu/etd_general_6/449

Identifier

FA00004255

Format

pdf