Date of Award
2011
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Abstract
Restrictive cardiomyopathy (RCM) is a heart muscle disease, characterized by diastolic dysfunction. The present dissertation is to understand the mechanisms underlyijng the initiation of diastolic dysfunction and the fast disease progression to early death in a RCM mouse model, the transgenic cTnI193His mouse... These data showed that myocardial ischemia occurred after diastolic dysfunction and before systolic dysfunction which proceeded congestive heart failure. The results demonstrate that myocardial ischemia causing cardiomycete death is a link between the initial diastolic dysfunction and late-stage systolic dysfunction, and accelerates the disease progression to fatal heart failure in the early age.
Extent
xii, 85 p. : ill. (some col.)
Recommended Citation
Li, Yuejin, "Pathogenesis of idiopathic restrictive cardiomyopathy" (2011). Electronic Theses and Dissertations 2010 - 2019. 355.
https://digitalcommons.fau.edu/etd_general_6/355
Identifier
FADT3362045
Comments
by Yuejin Li.|Thesis (Ph.D.)--Florida Atlantic University, 2011.|Includes bibliography.|Mode of access: World Wide Web.|System requirements: Adobe Reader.|by Yuejin Li.