Author Type

Graduate Student

Date of Award

2019

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

McAfee, Francis X.

Thesis/Dissertation Co-Chair

Blakely, Randy

Abstract

The blood brain barrier (BBB) is the brain’s defense mechanism in its maintenance of homeostasis. This network comprises an intricate, functional shield for the human brain, equipped with highly specialized cells like pericytes, astrocytic end-feet, endothelial and neuronal cells. This highly organized barrier maintains the brain’s structural integrity by revealing a discriminatory absorbency of molecules based on their molecular weight and ample fat solubility. In view of this impediment to the delivery of many prospective therapeutic agents from crossing the inviolate BBB, a myriad of innovative surgical and pharmacological interventions have been developed to bypass it, one of which is the BBBD protocol.

Extent

63 p.

Comments

Includes bibliography.|Thesis (M.F.A.)--Florida Atlantic University, 2019.|FAU Electronic Theses and Dissertations Collection|Includes bibliography.

Identifier

FA00013401

Format

pdf

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