Date of Award
2010
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Charles E. Schmidt College of Science
Abstract
Longitudinals lacking gene (LOLA) is a transcription factor that is involved in a variety of axon guidance decisions in Drosophila melanogaster nervous system. Besides having a role as an epigenetic silencer and in the programmed cell death in Drosophila's ovary, this gene is also an example of complex transcription unit. LOLA is a transcription repressor and can generate 17 DNA - binding isoforms, through alternative splicing, each containing distinct zinc-finger proteins. This unique DNAbinding binding sequence to which LOLA-ZFP binds has been determined for four of the lola isoforms F, J, P and K. Also, bioinformatics' tool approach has been taken to identify the target genes that are regulated by these four LOLA splice variants. Future work will be done for the five other LOLA isoforms to categorize their putative DNA-binding sequences and subsequently their protein interactions.
Extent
viii, 64 p. : ill. (some col.)
Recommended Citation
Qureshi, Bazila., "Identification of longitudinals lacking (LOLA) target genes in Drosophila melanogaster" (2010). Electronic Theses and Dissertations 2010 - 2019. 105.
https://digitalcommons.fau.edu/etd_general_6/105
Identifier
FADT2684893
Comments
by Bazila Qureshi.|Thesis (M.S.)--Florida Atlantic University, 2010.|Includes bibliography.|Electronic reproduction. Boca Raton, Fla., 2010. Mode of access: World Wide Web.|by Bazila Qureshi.