Author Type

Graduate Student

Date of Award

2003

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Neelakanta, Perambur S.

Abstract

This research refers to studies on information-theoretic (IT) aspects of data-sequence patterns and developing thereof discriminant algorithms that enable distinguishing the features of underlying sequence patterns having characteristic, inherent stochastical attributes. The application potentials of such algorithms include bioinformatic data mining efforts. Consistent with the scope of the study as above, considered in this research are specific details on information-theoretics and entropy considerations vis-a-vis sequence patterns (having stochastical attributes) such as DNA sequences of molecular biology. Applying information-theoretic concepts (essentially in Shannon's sense), the following distinct sets of metrics are developed and applied in the algorithms developed for data-sequence pattern-discrimination applications: (i) Divergence or cross-entropy algorithms of Kullback-Leibler type and of general Czizar class; (ii) statistical distance measures; (iii) ratio-metrics; (iv) Fisher type linear-discriminant measure and (v) complexity metric based on information redundancy. These measures are judiciously adopted in ascertaining codon-noncodon delineations in DNA sequences that consist of crisp and/or fuzzy nucleotide domains across their chains. The Fisher measure is also used in codon-noncodon delineation and in motif detection. Relevant algorithms are used to test DNA sequences of human and some bacterial organisms. The relative efficacy of the metrics and the algorithms is determined and discussed. The potentials of such algorithms in supplementing the prevailing methods are indicated. Scope for future studies is identified in terms of persisting open questions.

Extent

395 p.

Comments

College of Engineering and Computer Science|FAU Electronic Theses and Dissertations Collection|Thesis (Ph.D.)--Florida Atlantic University, 2003.|College of Engineering and Computer Science

Identifier

FADT12057

Format

pdf

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