Author Type

Graduate Student

Date of Award

2003

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Hartmann, James X.

Abstract

This project used a bioinformatics approach to identify the genetic differential expression of chronic lymphocytic leukemia (CLL) white blood cells as compared to normal white blood cells. Several public access databases and data mining tools were used to collect these data. The data collected was validated by independent bioinformatics databases and the methodology was supported by previously published "gene chip" differential expression data. This research identifies a pattern of differential gene expression specific to CLL white blood cells that can be used for the early diagnosis of CLL. The study also identifies the probable genetic origin for the low expression of tyrosine kinase and IgM immunoglobulin observed in CLL B-cells. Also presented are genes associated with chromosomal regions previously reported as deleted in a high percentage of CLL cases. These data can be used in further research and for the treatment of CLL.

Extent

89 p.

Comments

Thesis (M.S.)--Florida Atlantic University, 2003.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection|Thesis (M.S.)--Florida Atlantic University, 2003.

Identifier

FADT13024

Format

pdf

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