Date of Award
2009
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Abstract
In sea turtles, the study of the etiology and development of fibropapillomatosis is not fully understood. Sea turtle fibropapillomatosis is a disease characterized by the proliferation of skin fibropapillomas and occasional internal fibromas. In this study, sea turtle fibropapilloma tumor and healthy tissue samples were used to look at VEGF, BCL-2 and Bax expression. Cancer tumors have a well established pattern of protein expression that involves overexpression of vascular endothelial growth factor (VEGF), responsible for the growth of new blood vessels, and a high BCL-2 to Bax ratio that leads to uncontrolled cell proliferation. Real time PCR was used to analyze VEGF expression, and Western blot techniques were used to measure BCL-2 and Bax expression. The results indicated that expression of VEGF was not significantly higher in tumor vs. skin tissue. For the differential expression of BCL-2 and Bax, the results were not in agreement with the established levels found in cancer studies, showing no significant change in BCL-2 expression and significantly higher levels of Bax in tumor vs. healthy tissue.
Extent
x, 58 p. : ill. (some col.).
Recommended Citation
Bancalari-Schmidlapp, Angela., "Vascular endothelial growth factor (VEGF), BCL-2, and BAX expression in fibropapilloma tumor tissue and skin tissue of sea turtles" (2009). Electronic Theses and Dissertations 2000 - 2009. 1811.
https://digitalcommons.fau.edu/etd_general_5/1811
Identifier
FADT209981
Comments
by Angela Bancalari-Schmidlapp.|Thesis (M.S.)--Florida Atlantic University, 2009.|Includes bibliography.|Electronic reproduction. Boca Raton, Fla., 2009. Mode of access: World Wide Web.|by Angela Bancalari-Schmidlapp.