Date of Award
2008
Document Type
Dissertation
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
lsgor, Ceylan
Abstract
In this thesis I studied propensity for behavioral sensitization to nicotine in the LRHR phenotype and associated plasticity in the hippocampal mossy fiber morphology. I also investigated therapeutic effects of bupropion and a cannabinoid receptor antagonist on behavioral and morphological indices in adolescence and adulthood. Male rats were classified into high responders (HR) and low responders (LR) based on their locomotor response to a novel environment. LRHR animals underwent behavioral sensitization to nicotine and after one week of abstinence were challenged with a low dose of nicotine. HRs expressed behavioral sensitization to nicotine and showed an increase in hippocampal mossy fiber terminal field size. AM251 administration during abstinence reversed behavioral sensitization in HRs and bupropion only attenuated the locomotor response to na"ive nicotine exposure. Therapeutic agents had differential effects on mossy fiber morphology dependent on phenotype and age.
Extent
100 p.
Recommended Citation
Bhatti, Amrinder S., "Behavioral sensitization to nicotine in the novelty-seeking phenotype and hippocampal mossy fiber morphology" (2008). Electronic Theses and Dissertations 2000 - 2009. 1423.
https://digitalcommons.fau.edu/etd_general_5/1423
Identifier
FA00000727
Comments
Includes bibliography.|Dissertation (Ph.D.)--Florida Atlantic University, 2008.|Charles E. Schmidt College of Medicine|FAU Electronic Theses and Dissertations Collection|Includes bibliography.