Date of Award
2000
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Kerr, Russell G.
Abstract
Ecteinascidin 743 is a trace secondary metabolite isolated from the marine tunicate, Ecteinascidia turbinata. Ecteinacidin 743 a most potent antitumor agent, is currently in Phase II clinical trials in Europe and in the USA. A cell-free extract of Ecteinascidia turbinata was used to investigate the biogenetic origin of the ecteinascidins. Incubation experiments with radiolabeled diketopiperazines indicated that the diketopiperazine of tyrosine is the first committed intermediate in the biosynthesis of ecteinascidins. Phenylalanine diketopiperazine was not transformed into the ecteinascidins indicating that this cyclic dipeptide is not an intermediate in the biosynthesis of ecteinascidins. The diketopiperazine of DOPA was used as a cold carrier demonstrating that the diketopiperazine of tyrosine is oxidized to DOPA diketopiperazine and then further transformed to the ecteinascidins.
Extent
99 p.
Recommended Citation
Jeedigunta, Shanti, "Synthesis and testing the intermediacy of diketopiperazines in the biosynthesis of ecteinascidins" (2000). Electronic Theses and Dissertations 2000 - 2009. 141.
https://digitalcommons.fau.edu/etd_general_5/141
Identifier
FADT15754
Comments
Charles E. Schmidt College of Science|Thesis (M.S.)--Florida Atlantic University, 2000.|FAU Electronic Theses and Dissertations Collection|Charles E. Schmidt College of Science