Author Type

Graduate Student

Date of Award

2007

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Tuller, Betty

Abstract

The current study uses a diabetic rat model to measure the effects of pulsatile versus continuous insulin delivery on IRS-2 in the liver. The purpose is to determine if pulsatile, compared with continuous, insulin delivery leads to reduced insulin resistance in diabetic rats. Insulin signaling in the liver is mediated primarily through IRS-2 and tissue responsiveness to insulin may be detected by monitoring the lRS-2 signaling pathway. Western blots were performed to measure IRS-2 protein levels for each delivery condition and treatment day. Results revealed that overall, the pulsatile insulin delivery method showed a significant increase in IRS-2 levels over the continuous insulin delivery method by treatment day 5. These findings imply that the pulsatile delivery method, over a period of time, triggers more insulin receptor action. Conversely, the results of the continuous delivery system show a decrease in IRS-2 levels as the number of doses of insulin increased.

Extent

34 p.

Comments

Charles E. Schmidt College of Science|Thesis (M.A.)--Florida Atlantic University, 2007.|Charles E. Schmidt College of Science

Identifier

FA00000818

Format

pdf

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