Author Type

Graduate Student

Date of Award

2007

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Cudic, Predrag

Abstract

A novel carbohydrate receptor based on the structure of the antibiotic polymxin B was synthesized. The receptor was a cyclic heptapeptide. which was bridged using 2, 2'-bi pyridine-5,5"- dicarboxylic acid. The association constants of the receptor and a variety of sugars were determined using UV /Vis and fluorescence spectroscopy and observed log K0 values are in the range from 3 .8 to 4.1 for the pentoses, logKa 3.3 to 3.8 for the hexoxes and 0 to 2.9 logKa values from 0-2.9 for disaccharides and logKa of2.6 to 3.11 for the charged sugars. We demonstrated that polymixin based receptors are capable of binding various monosaccharide substrates in aqueous media, displaying structure selectivity with respect to monosaccharide ring size.

Extent

106 p.

Comments

Includes bibliography.|Thesis (M.S.)--Florida Atlantic University, 2007.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection|Includes bibliography.

Identifier

FA00000776

Format

pdf

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