Date of Award
2006
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Louda, Deborah W.
Abstract
A large number of metal-containing compounds show significant activity against cancer cells and incorporating a metal into a polymer offers several possible advantages. Compounds of the type R2SnCl2 (R = methyl, ethyl, propyl, butyl, t-butyl, octyl and phenyl) were tested for the ability to inhibit the growth of Balb 3T3 mouse fibroblast cells and CAOV3 human ovarian carcinoma cells. Polymers of 2-chloro-1,4-benzenediamine and the same organotin dichloride were synthesized and tested as well. For both monomers and polymers, the pattern of growth inhibition relative to the R group was butyl > propyl = t-butyl = octyl = phenyl > ethyl > methyl. This and other aspects of the structure-activity relationship of the monomers and polymers were examined.
Extent
165 p.
Recommended Citation
Doucette, Randy D., "Initial evaluation of organotin monomers and polymers as potential anticancer agents" (2006). Electronic Theses and Dissertations 2000 - 2009. 1086.
https://digitalcommons.fau.edu/etd_general_5/1086
Identifier
FADT13410
Comments
Thesis (M.S.)--Florida Atlantic University, 2006.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection|Thesis (M.S.)--Florida Atlantic University, 2006.