Comparison of alkyl-bonded alumina and silica stationary phases for peptide and protein separations by high performance liquid chromatography

Author

• David Clinton Williams

Author Type

Graduate Student

Date of Award

1996

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Haky, Jerome E.

Abstract

The applicability of a recently developed octadecylalumina (ODA) stationary phase for the preparative separations of proteins and peptides is compared with that of conventional Octadecylsilica (ODS) phases. Chromatographic peak widths, peaks areas, and recoveries of polypeptides were obtained from both types of phases. The ODA phase compares favorably with the ODS phase on small peptides, but exhibits low recoveries on high molecular weight proteins. The results are attributed to the unique fused-microplatelet shape of the ODA particles.

Extent

77 p.

Comments

Thesis (M.S.)--Florida Atlantic University, 1996.|Thesis (M.S.)--Florida Atlantic University, 1996.

Recommended Citation

Williams, David Clinton, "Comparison of alkyl-bonded alumina and silica stationary phases for peptide and protein separations by high performance liquid chromatography" (1996). Electronic Theses and Dissertations 1990 - 1999. 885.
https://digitalcommons.fau.edu/etd_general_4/885

Identifier

FADT15260

Format

pdf