Date of Award
1995
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Kerr, Russell G.
Abstract
Cephalostatin 1 has been isolated from the colonial marine worm Cephalodiscus gilchristi (Phylum Hemichordata) in the Indian Ocean. It has shown biomedical potential in preclinical trials as a cell growth inhibitor, active against U. S. murine P388 lymphocyte leukemia ED5010^-7-10^-9 μ/ml and a potent growth inhibitor against solid tumor types. Our research is focusing on developing methodology to produce disteroidal pyrazine and the introduction of delta 14, 15 unsaturation and C-16 hydroxyl groups in Cephalostatin 1A. The synthetic intermediates may be useful for biosynthetic studies and also analogues can be used to study structure-activity relationships.
Extent
111 p.
Recommended Citation
Wu, Mao, "Studies towards the synthesis of Cephalostatin 1" (1995). Electronic Theses and Dissertations 1990 - 1999. 842.
https://digitalcommons.fau.edu/etd_general_4/842
Identifier
FADT15169
Comments
Thesis (M.S.)--Florida Atlantic University, 1995.|Thesis (M.S.)--Florida Atlantic University, 1995.