efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis

Author

• Hafusat Abosede Fawehinmi

Author Type

Graduate Student

Date of Award

1999

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Kerr, Russell G.

Abstract

The ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate using oxidative deamination of cysteine by amino acid oxidase.

Extent

66 p.

Comments

Thesis (M.S.)--Florida Atlantic University, 1999.|Thesis (M.S.)--Florida Atlantic University, 1999.

Recommended Citation

Fawehinmi, Hafusat Abosede, "efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis" (1999). Electronic Theses and Dissertations 1990 - 1999. 1442.
https://digitalcommons.fau.edu/etd_general_4/1442

Identifier

FADT15725

Format

pdf