Author Type

Graduate Student

Date of Award

1999

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Terry, Leslie M.

Thesis/Dissertation Co-Chair

Johanson, Ingrid B.

Abstract

The effects of cocaine exposure and maternal deprivation on subsequent voluntary ingestion of cocaine and amphetamine was investigated in 7-day-old rat pups in order to further our understanding on the development of drug addiction. Maternally deprived and non-deprived pups were pre-exposed to a cocaine solution masked with 5% orange Tang solution. Four hours later, experimental pups were tested for subsequent cocaine self-administration (SA) (Exp. 1) or amphetamine SA, (Exp. 2), following a second deprivation period. Control pups were not deprived during this interval. Pups in both experiments were assessed for dose self-administered and for general activity. Results indicate that cocaine pre-exposure increased cocaine and amphetamine SA, and activity significantly increased after pre-exposure and testing sessions. Lastly, sensitization of the motor effects of cocaine was observed in pups pre-exposed to cocaine. This study provides a potential drug SA animal model not yet investigated in developing animals.

Extent

65 p.

Comments

FAU Electronic Theses and Dissertations Collection|Thesis (M.A.)--Florida Atlantic University, 1999.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection

Identifier

FADT15745

Format

pdf

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