Date of Award
1997
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Wolgin, David L.
Abstract
The purpose of this experiment was to determine if tolerance to cocaine-induced hypophagia involves learning to suppress stereotyped movements that interfere with feeding. Milk intake and motor activity were measured in rats fed via bottles or intraoral cannulas. On dose-response 1, the bottle group was more hypophagic than the cannula group at the 8, 16, and 32 mg/kg doses. After 60d of chronic cocaine (16 mg/kg), only the bottle-fed group showed tolerance, indicated by a shift to the right on dose-response 2. Tolerance was accompanied by a decrease in activity, while activity in the cannula-fed groups given 16 or 32 mg/kg showed sensitization. These results suggest that moderate doses of cocaine interfere with feeding primarily by producing incompatible behaviors. Tolerance involves learning to inhibit these behaviors in order to feed.
Extent
63 p.
Recommended Citation
Hertz, Jacqueline Moore, "Effects of daily cocaine on milk intake and motor activity in cannula-fed and bottle-fed rats" (1997). Electronic Theses and Dissertations 1990 - 1999. 1118.
https://digitalcommons.fau.edu/etd_general_4/1118
Identifier
FADT15464
Comments
Thesis (M.A.)--Florida Atlantic University, 1997.|Thesis (M.A.)--Florida Atlantic University, 1997.