Date of Award
1997
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Kerr, Russell G.
Abstract
The bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia, melanoma and nephrotoma. A series of experiments was undertaken to elucidate the biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme preparation and radiolabelled precursors. A regional characterization of Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also described.
Extent
98 p.
Recommended Citation
Lawry, Joseph, "Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina" (1997). Electronic Theses and Dissertations 1990 - 1999. 1066.
https://digitalcommons.fau.edu/etd_general_4/1066
Identifier
FA00000787
Comments
Includes bibliography.|Thesis (M.S.)--Florida Atlantic University, 1997.|Charles E. Schmidt College of Science|Includes bibliography.