Author Type

Graduate Student

Date of Award

1989

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Siegmann, Deborah

Abstract

Cis-DDP is a chemotherapeutic drug which has been very useful in the treatment of testicular and ovarian cancers. Recently, polymeric drugs modeled after cis-DDP have been developed by reacting potassium tetrachloroplatinate with various diamines. Previous testing of these analogs on cells indicated that many were cytotoxic. To see if the cytotoxic effects were the result of inhibition of DNA synthesis as is thought to be the case for cis-DDP, 3H-thymidine incorporation studies were carried out on polymer-treated cells. The results were compared to incorporation studies from cis-DDP-treated cells and found to be similar. The results from the DNA synthesis studies were compared to cytotoxic results, and they indicated that inhibition of DNA synthesis may be responsible for the cytotoxic effects of the polymers. The size of a polymer was found to be unimportant in determining its effectiveness.

Extent

152 p.

Comments

Thesis (M.S.)--Florida Atlantic University, 1989.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection|Thesis (M.S.)--Florida Atlantic University, 1989.

Identifier

FADT14547

Format

pdf

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