Author Type

Graduate Student

Date of Award

1988

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Abstract

Increased risk for cancer in individuals with hereditary adenomatosis of the colon and rectum (ACR) has been hypothesized as resulting from a regulatory gene mutation which allows the tissue specific partial expression of a growth factor. Eight ACR and 4 normal control dermal fibroblast cell strains were grown at various concentrations of dialyzed serum protein in MCDB 104. Normal and ACR strains grew best at similar serum concentrations and grew at similar rates in low serum concentrations. Growth rates of normal and ACR strains declined similarly with increasing cell density. The equation Y = (AX/(X + B)) - CX was developed to analyze the shape of the serum dose response curves, where: Y = growth rate, X = serum protein concentration, and values of A, B, and C are constants. The A, B, and C constants for 4 normal and 4 ACR cell strains were found to be similar. It was concluded that there was no evidence for the constitutive production of a growth factor in ACR dermal fibroblasts.

Extent

176 p.

Comments

FAU Electronic Theses and Dissertations Collection|Thesis (M.S.)--Florida Atlantic University, 1988.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection

Identifier

FADT14434

Format

pdf

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