Author Type

Graduate Student

Date of Award

1985

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Abstract

To access the contribution of anorexia and motor activation in amphetamine-induced suppression of feeding, rats given chronic injections of either saline or amphetamine (2 or 4 mg/kg) were offered milk either directly into the mouth through an intraoral cannula or in a standard drinking bottle. It was reasoned that although druginduced anorexia would affect intake with both methods of feeding to the same degree, the disruptive effect of motor activation would be greater in bottle-fed rats. Consistent with this prediction, intakes of drugged rats were lower in bottle-fed rats than in cannula-fed rats. Recovery of intake occurred in all drugged rats except those given 4 mg/kg and fed by bottle. Among the tolerant groups, rats fed by bottle and given 2 mg/kg recovered at a faster rate than cannual fed rats at either dose. These results suggest that motor activation contributes to reduced intake and that adaptation to the stimulant effects of the drug plays a primary role in the development of tolerance.

Extent

37 p.

Comments

FAU Electronic Theses and Dissertations Collection|Thesis (M.A.)--Florida Atlantic University, 1985.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection

Identifier

FADT14250

Format

pdf

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