Date of Award
1983
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Hartmann, James X.
Abstract
Three antiviral compounds, 5-iodo-2' -deoxyuridine (IUDR), 9-(2-hydroxyethoxymethyl )guanine (acyclovir) and methylglyoxal-bis-(guanylhydrazone) MGBG were tested for their effectiveness against Pacheco's disease virus (PDV). IUDR caused a fifty percent reduction in plaque formation (PR50) at 0 .8 μM in chicken embryo fibroblasts while acyclovir showed a PR50 of 6.6 μM. Plaque inhibition assays showed a significant decrease in plaque size (1.25 mm to 0.45 mm) at 10 μM acyclovir and (1.3 mm to 0.5 mm) at both 1 μM and 10 μM of IUDR. MGBG did not reduce virus replication vitro, and an apparent reduction of virus growth in vivo was probably due to toxicity. However, in vitro toxicity studies did not show any significant reduction in cell growth with any of the compounds tested.
Extent
89 p.
Recommended Citation
AVERY, PATRICIA OTTENS, "EFFECTIVENESS OF ANTI-HERPETIC COMPOUNDS ON PACHECO'S DISEASE VIRUS OF PSITTACINES" (1983). Electronic Theses and Dissertations 1980 - 1989. 238.
https://digitalcommons.fau.edu/etd_general_3/238
Identifier
FADT14145
Comments
Thesis (M.S.)--Florida Atlantic University, 1983.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection|Thesis (M.S.)--Florida Atlantic University, 1983.