Author Type

Graduate Student

Date of Award

1981

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Wolgin, David L.

Abstract

Rats with lesions of the ventromedial aspect of the internal capsule in the vicinty of the entopeduncular nucleus (EP) showed a loss of forelimb placing (chin, contact and visual) in the contralateral limb. Spreading depression induced by instillation of KCl (25%) to the cortex contralateral to the lesion brought back placing in the affected limb and abolished placing in the normal limb. Within 24 hours the pre-spreading depression state returned and the impaired limb no longer placed while the normal limb recovered function. In contrast, KCl on the ipsilateral cortex did not reinstate placing. These results suggest that the loss of placing following lesions of the EP are due to tonic inhibition from the cortex contralateral to the lesion. Sensory summation was evident during the early recovery period when placing was accomplished only if two kinds of stimuli were provided simultaneously. Forelimb placing recovered to its pre-lesion state.

Extent

53 p.

Comments

Thesis (M.A.)--Florida Atlantic University, 1981.|Charles E. Schmidt College of Science|FAU Electronic Theses and Dissertations Collection|Thesis (M.A.)--Florida Atlantic University, 1981.

Identifier

FADT14078

Format

pdf

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