Author Type

Graduate Student

Date of Award

1976

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Abstract

The effects of rat peritoneal macrophages and peripheral blood lymphocytes on syngeneic Rous sarcoma virus-transformed tumor cells were studied. Normal lymphocytes and peptoneinduced macrophages of non-tumor bearing Wistar rats prevented tumor cell incorporation of 3H-thymidine by 50-78%. Macrophages of rats which had been injected with 1 x 10^6 ultraviolet inactivated tumor cells lost their original antitumor activity (60% inhibition) by day 10 (20% inhibition) and appeared to regain it slightly by day 17. Lymphocytes from immunized animals did not exhibit anti-tumor activity but instead enhanced the incorporation of thymidine into the tumor cells by 25%. By day 17, all anti-tumor activity returned to lymphocytes, whereas macrophage activity only slightly increased. A possible explanation of the phenomenon was presented. Parameters affecting the incorporatidn of 3H-thymidine by and ultraviolet inactivation of tumor cells were delineated.

Extent

81 p.

Comments

FAU Electronic Thesis or Dissertation Collection|Thesis (M.S.)--Florida Atlantic University, 1976.|FAU Electronic Thesis or Dissertation Collection

Identifier

FADT13795

Format

pdf

Download

Share

COinS