Author Type

Graduate Student

Date of Award

1974

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Abstract

Liver, kidney and spleen cells from healthy horses and horses with equine infectious anemia were cultured in vitro. Primary culture of organs from healthy horses yielded typical elongate fibroblast cells. Primary culture of organs from diseased horses yielded a variety of cell types; pleomorphic giant cells being most common. The giant cells did not divide, but either underwent degeneration and death or became transformed into squamous-like cells lacking contact inhibition resulting in the production of foci. Inoculation of normal equine fibroblasts with either serum, plasma, or liver, kidney or spleen extracts from diseased horses resulted in a proliferation of the fibroblasts. Normal liver or kidney fibroblasts cocultivated with equine leucocytes and inoculated with serum or plasma from a diseased horse became transformed. This research supports the proposal that equine infectious anemia virus is an oncornavirus.

Extent

76 p.

Comments

Thesis (M.S.)--Florida Atlantic University, 1974.|Thesis (M.S.)--Florida Atlantic University, 1974.

Identifier

FADT13651

Format

pdf

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