Isolation and Biomimetic Synthesis of Marine Natural Products from the Gorgonian Briareum Asbestinum
Date of Award
2021
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
West, Lyndon M.
Abstract
Throughout history, natural products have produced a plethora of biologically active compounds that have established applications in medicine, biology, and pharmacy. The exploration for improved cytotoxic agents has continued to be a crucial path in natural products drug discovery. The focal point of this thesis sheds light on the biosynthetic relationship between the two distinct classes of briarane diterpenoids, the γ-lactone briarane and the briareolate esters. Additionally, this study elaborates on the discovery and elucidation of structurally unique secondary metabolites from the gorgonian coral Briareum asbestinum. The first chapter of this thesis provides a review of the development and discovery of diverse secondary metabolites. In addition, this chapter describes the role of natural products in drug discovery and summarizes the research progress in marine natural product chemistry in conjunction with a detailed overview of the current marine-derived pharmaceuticals.
Extent
206 p.
Recommended Citation
Simpson, Johnathon, "Isolation and Biomimetic Synthesis of Marine Natural Products from the Gorgonian Briareum Asbestinum" (2021). Electronic Theses and Dissertations 2020 - Present. 760.
https://digitalcommons.fau.edu/etd_general/760
Identifier
FA00013857
Comments
Includes bibliography.|Thesis (MS)--Florida Atlantic University, 2021.|FAU Electronic Theses and Dissertations Collection|Includes bibliography.