Date of Award
2020
Document Type
Thesis
Publication Status
Version of Record
Submission Date
October 2026
Thesis/Dissertation Advisor [Chair]
Fields, Gregg B.
Thesis/Dissertation Co-Chair
Leventouri, Theodora
Abstract
Matrix Metalloproteinase-13 (MMP-13) belongs to a large family of proteolytic enzymes which are characterized by their ability to degrade the extracellular matrix components. MMP-13 appears to have a critical role in tumor invasion and metastasis. In this study, several fluorogenic probes specific for MMP-13 were designed and characterized. These synthesized probes could be modified with chelators to be applied for imaging MMP-13 in breast cancer and/or multiple myeloma models. The activity and selectivity of MMP-13 and other MMPs against these probes were studied through two approaches. It was found that these probes were cleaved by all MMPs, but MMP-13 showed the highest activity and selectivity towards these peptides.
Extent
73 p.
Recommended Citation
Ibrahim, Mariam, "Synthesis of Fluorogenic Probes Specific for Matrix Metalloproteinase 13" (2020). Electronic Theses and Dissertations 2020 - Present. 593.
https://digitalcommons.fau.edu/etd_general/593
Identifier
FA00013507
Comments
Includes bibliography.|Thesis (M.S.)--Florida Atlantic University, 2020.|FAU Electronic Theses and Dissertations Collection|Includes bibliography.