Author Type

Graduate Student

Date of Award

2024

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Ranji, Mahsa

Abstract

Significant efforts are being made to understand and treat cancer, though methods are costly, invasive, and detrimental to healthy surrounding tissues. Techniques in optical imaging assess cancer cells’ state in response to treatments. The purpose of this study is to employ non-ionizing radiation as a potential safer therapeutic option and use timelapse fluorescence microscopy to monitor and quantify treatments to lung cancer cells. This thesis (1) measures and visualizes effects of a combinatory repurposed drug treatment through monitoring cellular metabolic state with time-lapse fluorescence microscopy and (2) develops a non-ionizing electromagnetic radiation system as a possible therapy modality. Results obtained demonstrate the effectiveness of a combinatory drug treatment and promising capability of non-ionizing radiation treatment, determined by an increase in fluorescence intensity correlated with metabolic state. In the future, different irradiation doses and drug combinations will be used for additional cancer cell lines, such as prostate and breast cancer.

Extent

102 p.

Comments

Includes bibliography.|Thesis (MS)--Florida Atlantic University, 2024.|FAU Electronic Theses and Dissertations Collection|Includes bibliography.

Identifier

FA00014406

Format

pdf

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