Author Type

Graduate Student

Date of Award

2024

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Ranji, Mahsa

Abstract

Metabolic dysfunction can present in conditions like cancer and neurodegeneration. Optical imaging techniques were employed to assist in the diagnosis and understanding of disease pathologies. A cryomesoscopy modality was designed and incorporated into an imaging device to investigate metabolic biomarkers. The new lens design provided higher magnifications and resolution of tissue data. The improved imaging capabilities gave detailed access to structural and biochemical changes that occur in disease progression. Cryomesoscopy was applied to study mitochondrial redox state in preclinical models of Alzheimer’s and cancer. The optical imaging tools were utilized to visualize the livers and kidneys of mutated mice and investigate their metabolic states. The results in both investigations revealed oxidized metabolic states, a marker of oxidative stress and metabolic dysfunction. The cryomesoscopy system has proven instrumental in quantifying metabolic shifts and offers new insights into disease pathologies. Optical imaging can be applied to understanding metabolic mechanisms in many diseases.

Extent

102 p.

Comments

Includes bibliography.|Thesis (MS)--Florida Atlantic University, 2024.|FAU Electronic Theses and Dissertations Collection|Includes bibliography.

Identifier

FA00014404

Format

pdf

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