Author Type

Graduate Student

Date of Award

2023

Document Type

Thesis

Publication Status

Version of Record

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Hartmann, James

Abstract

Prostate cancer, the most frequent non-skin cancer, is the second leading cause of cancer-related deaths in males within the United States. Men diagnosed with metastatic prostate cancer have a 5-year survival rate of approximately 30%. Goals of this study were to produce a combination of compounds that are effective against the disease with minimal side effects on normal cells, especially those of the immune system. This study showed KBU2046 in combination with calcitriol, limit proliferation, inhibit migration, and are cytotoxic in a testosterone dependent human prostate cancer cell line. Organic compounds, ellagic acid and curcumin were tested alone and in combination with either calcitriol or KBU2046. No combinations were as effective as KBU2046 and calcitriol in inhibiting migration and proliferation of LNCaP cells. The findings of this study support further investigation into therapeutic use of a combination of KBU2046 and calcitriol in prevention and remission of human prostate cancer.

Extent

102 p.

Comments

Includes bibliography.|Thesis (MS)--Florida Atlantic University, 2023.|FAU Electronic Theses and Dissertations Collection|Includes bibliography.

Identifier

FA00014242

Format

pdf

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