•  
  •  
 

Florida Atlantic Undergraduate Research Journal

College

Charles E Schmidt College of Science

Document Type

Article

Abstract

CRISPR-Cas9 is a genetic engineering technology that allows for precise editing of DNA sequences. It utilizes a guide RNA that targets the endonuclease Cas9 to make a double-strand DNA break at a specific site. This technology has proven useful in both clinical and biomedical settings. This review discusses some prominent applications including treatment of Transthyretin Amyloidosis, cell cloning for pharmaceuticals, refractory cancer, sickle cell disease and β-Thalassemia. Furthermore, two methods that utilize CRISPR-Cas9 to prevent hereditary retinoblastoma are proposed.

Advisors

David Binninger

Share

COinS