PTFE tape as a phase screen in the synthesis of chiral α-halo ethers and acetals

Author

• Salvatore Crusco

Date of Award

2011

Document Type

Dissertation/Thesis

Submission Date

October 2026

Thesis/Dissertation Advisor [Chair]

Dragojlovic, Veljko

Abstract

In organic synthesis, the phase-vanishing (PV) technique uses an organofluoride solution to keep two reactive solutions in separate layers, while allowing a reaction to proceed at the interface of the fluorous layer. PV reactions allow otherwise vigorous reactions to proceed at a slower, more controlled rate. In this research, we evaluated the use of PTFE tape as a phase screen in the synthesis of chiral α-halo ethers and acetals. We were successful in synthesizing the two compounds of interest, and also successful in their isolation through the use of column chromatography. Since α-halo ethers are known to be carcinogenic, the use of PTFE tape minimizes exposure to the potentially harmful substance.

Comments

Includes bibliography.

Recommended Citation

Crusco, Salvatore, "PTFE tape as a phase screen in the synthesis of chiral α-halo ethers and acetals" (2011). Harriet L Wilkes Honors College Theses 2010 - 2019. 51.
https://digitalcommons.fau.edu/etd_honors_2/51

Extent

22 p.

Identifier

FA00003572